OVERVIEW:
| Monoclonal RELA antibody, Anti-RELA antibody, Reticuloendotheliosis viral oncogene homolog A antibody, Anti RELA antibody, RELA antibody, Reticuloendotheliosis viral oncogene homolog A antibody |
| Human RELA |
| Human, Rat. Other species not studied |
| Dot Blot, ICC, WB |
| RELA antibody was raised in mouse using recombinant Human V-Rel Reticuloendotheliosis Viral Oncogene Homolog A,Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3, P65 (Avian) |
SPECIFICATIONS:
| Mouse |
| 340C1a |
| IgG1 |
| RELA antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| RELA antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ). |
| 100 ug/ml |
STORAGE & SAFETY:
| Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing. |
| This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv |
Usage Assay Information:
| WB: 0.2-2 ug/ml, ICC: 2-100 ug/ml |
GENERAL INFORMATION:
| NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. |
